| Methods |
Randomised, controlled, cross‐over trial. |
| Participants |
18 adults (6 males, 12 females) with FH on cholesterol‐lowering drug therapy. Mean (SEM) age of 48 (2) years). |
| Interventions |
Low fat plant sterol ester spread or low fat plant stanol ester spread over over and above ongoing drug therapy. |
| Outcomes |
Total, VLDL, HDL & LDL cholesterol, triglycerides, Apo‐B and non‐cholesterol sterols. |
| Notes |
NB: Only short term outcomes were assessed; No treatment period involved a phase of lipid‐lowering drug given alone. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
Stated 'randomised' but method not described. |
| Allocation concealment (selection bias) |
Unclear risk |
Unclear. |
| Blinding (performance bias and detection bias)
All outcomes |
Low risk |
Described as double‐blind, but not stated who was blinded. |
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
Intention‐to‐treat analysis was considered adequate. |
| Selective reporting (reporting bias) |
Low risk |
All the outcomes stated in methods were reported |
