Table 1.

Cell-cell junction proteins in developing tendon.

Cell-Cell Junction Type		Possible Functions In Developing Tendon	References
Cadherins	N-cadherin	Cellular condensation, cell adhesion, limb patterning	Hasson 201042 Luo 200541 Luo 200140 Richardson 200737
	R-cadherin	Unknown role in embryonic tendon, but expression identified in E13 chick metatarsal tendon	Kimura 199539 Richardson 200737
	Cadherin-4	Unknown role in embryonic tendon, but expression identified in mesodermal cell precursors in chick at HH25	Lorda-Diez 201455
	Cadherin-7	Unknown role in embryonic tendon, but required for cell condensation and migration in chick limb mesenchymal cells	Kim 200974
	Cadherin-11	Cellular condensation, distinction of cartilage and tendon precursors, limb patterning, collagen fibril alignment	Kimura 199539 Richardson 200737
	Cadherin-13	Unknown role, but identified in tendon cells at P1	Smith 201273
	Protocadherin-15	Unknown role, but identified in tendon cells at P1	Smith 201273
	Fat-1	Cell proliferation, patterning of muscle and tendon precursors, overlapping expression domain with scleraxis, limb patterning.	Helmbacher 201846 Smith 200751
	Fat-4	Unknown role, but identified in tendon cells at P1	Smith 201273
Connexins	Connexin-32	Mechanotransduction, stimulation of collagen production	McNeilly 199612 Russo 201567 Stanley 200738 Wagget 200666
	Connexin-43	Mechanotransduction, inhibition of collagen production, separation of cartilage and tendon precursors, cell condensation, tissue patterning	Coleman 2003a68 Coleman 2003b75 McNeilly 199612 Russo 201567 Stanley 200738 Wagget 200666
Tight Junctions	ZO-1 and Claudin-1	Epithelium surrounding tendons – containment of tendon cells within tendon and prevention of tendinopathic adhesions	Taylor 201176