Skip to main content
. Author manuscript; available in PMC: 2020 Mar 10.
Published in final edited form as: Cell Physiol Biochem. 2019;52(6):1569–1583. doi: 10.33594/000000109

Fig. 6.

Fig. 6.

MCA Kir2.1 channels are critical components of FIV. A) FIV curves produced by exposing MCAs from WT and Kir2.1+/− mice to intraluminal flow via the pressure gradient method. Vasodilation is shown as the percent dilation to baseline diameters recorded at physiological pressure (~44 mm Hg) after pre-constriction with ET-1 (120–200 pM) to ~50% of baseline. BaCl2 (30 μM) is used to block Kir channels and reduce FIV as previously reported [10]. B) Dilations to Δ100 cm H2O intraluminal flow reveal 1) significant inhibition of FIV by Ba2+ in WT MCA (*p<0.05; repeated measures 2-way ANOVA) and 2) a significant difference in FIV between WT and Kir2.1+/−(*p<0.05; 2 way-ANOVA). No effect of Ba2+ was observed in Kir2.1+/− MCA.