Meunier 1990a.
Methods | Randomised, parallel group study conducted in Belgium. Patient, carer, assessor blind. No clear information on withdrawals given. No information on funding except all study drugs supplied by Pfizer. No dates for recruitment period. | |
Participants | Adults with mixed cancer. 40 patients enrolled, 37 completed. | |
Interventions | 2 groups. Ketoconazole 2 x 200 mg, once/day. Fluconazole 2 x 250 mg/day. Duration of therapy from 4 to 27 days, median 14 days. | |
Outcomes | Clinical eradication, and improvement. Assessment made at days 4 to 27. Microbiological eradication of initial pathogen (culture). | |
Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Adequate sequence generation? | Low risk | Quote: "Randomisation chart". |
Allocation concealment? | Low risk | Quote: "All study drugs were supplied by Pfizer and were administered in identical capsules". |
Blinding of participants and carers? | Low risk | Quote: "All study drugs were supplied by Pfizer and were administered as identical capsules". |
Blinding of outcome assessors? | Low risk | Quote: "....double‐blind". |
Incomplete outcome data addressed? | Low risk | Quote: "Forty patients enrolled in the study, 3 were excluded (8%) before the code was opened". Comment: The reasons were given but not by group as the code was not broken. It is felt not to be a source of bias. |
Free of selective reporting? | Low risk | Comment: Clinical and mycological eradication (culture). |
Free of other biases? | Unclear risk | No information on funding except all study drugs supplied by Pfizer. |