TABLE 3.
Differences in lipids between Model and Control group.
| No. | Lipid ion | Ion formula | CalMz | RT (min) | Fold change | P-value | OPLS-DA VIP | Change trend | Statistical significance |
| 43POS | AcCa(16:0)+H | C23 H46 O4 N1 | 400.3421355 | 3.04 | 1.77 | 0.046 | 1.09 | ↑ | * |
| 54POS | LPE(16:0e)+H | C21 H47 O6 N1 P1 | 440.3135535 | 3.8 | 2.26 | 0.030 | 1.30 | ↑ | * |
| 84POS | LPE(18:0)+H | C23 H49 O7 N1 P1 | 482.3241185 | 4.60 | 1.87 | 0.024 | 3.38 | ↑ | * |
| 143POS | LPS(18:0)+H | C24 H49 O9 N1 P1 | 526.3139485 | 3.45 | 1.55 | 0.047 | 1.11 | ↑ | * |
| 499POS | SM(d34:1)+H | C39 H80 O6 N2 P1 | 703.5748525 | 11.17 | 1.60 | 0.016 | 1.75 | ↑ | * |
| 507POS | SM(d34:0)+H | C39 H82 O6 N2 P1 | 705.5905025 | 11.31 | 1.67 | 0.049 | 1.48 | ↑ | * |
| 543POS | PC(15:0/16:0)+H | C39 H79 O8 N1 P1 | 720.5537835 | 11.45 | 0.53 | 0.017 | 1.82 | ↓ | * |
| 625POS | PC(33:1)+H | C41 H81 O8 N1 P1 | 746.5694335 | 13.32 | 0.52 | 0.027 | 1.57 | ↓ | * |
| 735POS | PE(18:0p/22:6)+H | C45 H79 O7 N1 P1 | 776.5588685 | 12.53 | 0.47 | 0.010 | 1.08 | ↓ | * |
| 848POS | PC(38:4)+H | C46 H85 O8 N1 P1 | 810.6007335 | 12.08 | 0.49 | 0.036 | 1.91 | ↓ | * |
| 1363NEG | FA(20:4)-H | O2 H31 C20 | 303.2329535 | 5.27 | 0.51 | 0.023 | 1.25 | ↓ | * |
| 1460NEG | Cer(d18:2/16:0)+HCOO | C35 H66 O5 N1 | 580.4946475 | 11.33 | 1.72 | 0.021 | 3.23 | ↑ | * |
| 1490NEG | Cer(d18:0+pO/18:0)+HCOO | C37 H74 O6 N1 | 628.5521625 | 12.72 | 1.55 | 0.027 | 1.43 | ↑ | * |
| 1554NEG | PE(16:0/18:1)-H | C39 H75 O8 N1 P1 | 716.5235805 | 12.33 | 0.54 | 0.035 | 2.59 | ↓ | * |
| 1562NEG | PE(16:0p/20:4)-H | C41 H73 O7 N1 P1 | 722.5130155 | 11.87 | 0.55 | 0.047 | 7.24 | ↓ | * |
| 1567NEG | PE(36:3p)-H | C41 H75 O7 N1 P1 | 724.5286655 | 12.02 | 0.47 | 0.007 | 2.14 | ↓ | ** |
| 1598NEG | PE(18:0/18:2)-H | C41 H77 O8 N1 P1 | 742.5392305 | 12.52 | 0.34 | 0.040 | 2.91 | ↓ | * |
| 1605NEG | PE(16:0p/22:6)-H | C43 H73 O7 N1 P1 | 746.5130155 | 11.56 | 0.38 | 0.012 | 3.01 | ↓ | * |
| 1607NEG | PE(18:0/18:0)-H | C41 H81 O8 N1 P1 | 746.5705305 | 13.67 | 2.21 | 0.006 | 1.16 | ↑ | ** |
| 1610NEG | PG(16:0/18:1)-H | C40 H76 O10 N0 P1 | 747.5181615 | 11.56 | 0.44 | 0.024 | 2.07 | ↓ | * |
| 1613NEG | PE(18:1p/20:4)-H | C43 H75 O7 N1 P1 | 748.5286655 | 11.93 | 0.45 | 0.017 | 3.70 | ↓ | * |
| 1615NEG | PE(18:0p/20:5)-H | C43 H75 O7 N1 P1 | 748.5286655 | 12.21 | 0.30 | 0.030 | 2.23 | ↓ | * |
| 1617NEG | PG(18:0/16:0)-H | C40 H78 O10 N0 P1 | 749.5338115 | 11.93 | 0.38 | 0.004 | 3.67 | ↓ | ** |
| 1619NEG | PE(37:5)-H | C42 H73 O8 N1 P1 | 750.5079305 | 10.69 | 0.38 | 0.005 | 1.31 | ↓ | ** |
| 1644NEG | PE(16:0/22:6)-H | C43 H73 O8 N1 P1 | 762.5079305 | 11.11 | 0.26 | 0.003 | 1.05 | ↓ | ** |
| 1653NEG | PE(18:0/20:4)-H | C43 H77 O8 N1 P1 | 766.5392305 | 12.36 | 0.22 | 0.001 | 5.59 | ↓ | ** |
| 1656NEG | PE(18:0/20:3)-H | C43 H79 O8 N1 P1 | 768.5548805 | 12.55 | 0.19 | 0.000 | 2.25 | ↓ | ** |
| 1657NEG | PE(18:0/20:3)-H | C43 H79 O8 N1 P1 | 768.5548805 | 12.78 | 0.22 | 0.001 | 1.32 | ↓ | ** |
| 1659NEG | PG(16:0/20:4)-H | C42 H74 O10 N0 P1 | 769.5025115 | 10.21 | 0.20 | 0.025 | 1.50 | ↓ | * |
| 1660NEG | PE(18:0/20:2)-H | C43 H81 O8 N1 P1 | 770.5705305 | 13.37 | 0.17 | 0.001 | 1.01 | ↓ | ** |
| 1663NEG | PE(18:1p/22:6)-H | C45 H75 O7 N1 P1 | 772.5286655 | 11.64 | 0.21 | 0.005 | 1.27 | ↓ | ** |
| 1673NEG | PG(18:0/18:1)-H | C42 H80 O10 N0 P1 | 775.5494615 | 12.47 | 0.39 | 0.016 | 2.70 | ↓ | * |
| 1677NEG | PE(40:5p)-H | C45 H79 O7 N1 P1 | 776.5599655 | 12.66 | 0.41 | 0.005 | 2.14 | ↓ | ** |
| 1679NEG | PE(18:0p/22:5)-H | C45 H79 O7 N1 P1 | 776.5599655 | 13.22 | 0.40 | 0.017 | 1.51 | ↓ | * |
| 1681NEG | PG(36:0)-H | C42 H82 O10 N0 P1 | 777.5651115 | 12.67 | 0.48 | 0.027 | 1.38 | ↓ | * |
| 1684NEG | PE(20:0p/20:4)-H | C45 H81 O7 N1 P1 | 778.5756155 | 13.89 | 0.58 | 0.039 | 1.33 | ↓ | * |
| 1714NEG | PE(18:0/22:5)-H | C45 H79 O8 N1 P1 | 792.5548805 | 12.73 | 0.23 | 0.001 | 1.14 | ↓ | ** |
| 1720NEG | PE(18:0/22:4)-H | C45 H81 O8 N1 P1 | 794.5705305 | 13.05 | 0.31 | 0.001 | 2.374 | ↓ | ** |
| 1724NEG | PG(18:0/20:4)-H | C44 H78 O10 N0 P1 | 797.5338115 | 11.22 | 0.28 | 0.011 | 4.98 | ↓ | * |
| 1775NEG | PG(18:0/22:4)-H | C46 H82 O10 N0 P1 | 825.5651115 | 11.88 | 0.43 | 0.032 | 1.16 | ↓ | * |
| 1791NEG | PS(18:0/22:6)-H | C46 H77 O10 N1 P1 | 834.5290605 | 12.37 | 0.26 | 0.001 | 1.57 | ↓ | ** |
“↑” stands for upgrading, “↓”stands for downgrading. *Stands for significant difference (P < 0.05). **Stands for very significant difference (P < 0.01).