Figure 2.

Correlation between biofunction, genomic characteristics, and age. A, Age distribution of hallmarks of cancer in normal and GBM samples. Both normal and tumor tissue have hallmarks positively or negatively correlated with age. R and P values were obtained from the pearson correlation analysis between age and hallmark scores. A significant positive correlation was represented by red dots. A significant negative correlation was represented by blue dots. Gray dots represented no significant correlation. The calculation method of the hallmark scores is detailed in the methods section. B and C, Age distribution of GBM transcriptome subtypes. The yellow dots represent the classical subtype. The red dots represent the mesenchymal subtype. The green dots represent the neural subtype. The blue dots represent the proneural subtype. No significant difference was observed among the 4 subtypes. One‐way ANOVA analysis was performed to assess the statistical significance of variance. D, Overall genomic characteristics distribution ranked by age. No statistical difference was observed as age increased. Pearson correlation analysis was performed to assess the statistical significance between age and genome characteristics