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. 2019 Nov 13;23(1):1–11. doi: 10.1093/ijnp/pyz057

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© The Author(s) 2019. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 1. — Top of the figure displays the left and right anatomical amygdala seed-regions-of-interest (SOIs). Top of panel (A) shows a statistical t-map on a canonical brain illustrating the significant correlation between plasma brain-derived neurotrophic factor (BDNF) levels and left amygdala and medial prefrontal cortex (mPFC) connectivity during unpredictable threat (U-threat). Bottom of panel (A) displays a scatter plot of the correlation (P < .05) between plasma BDNF levels and extracted parameter estimates of amygdala-mPFC functional connectivity. Top of panel (B) shows a statistical t-map on a canonical brain illustrating the significant correlation between plasma BDNF levels and left amygdala and left inferior frontal gyrus (IFG) connectivity during unpredictable threat (U-threat). Bottom of panel (B) displays a scatter plot of the correlation (P < .05) between plasma BDNF levels and extracted parameter estimates of amygdala-IFG functional connectivity. (n = 24 controls; 33 alcohol use disorder [AUD] participants).