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. 2020 Mar 10;15(3):e0229558. doi: 10.1371/journal.pone.0229558

Fig 4. Comparison of nasal, non-nasal and all symptoms between participants inoculated with S. pneumoniae compared to those inoculated with normal saline (control).

Fig 4

Each bar chart shows the percentage of participants inoculated with S. pneumoniae (SPN) serotypes 6B and 23F (N = 46) and normal saline (control) (N = 8) reporting symptoms (nasal, non- nasal and all symptoms) after inoculation. Participants were deemed symptomatic if they scored >2, or >1 point above baseline for any of the five nasal or non-nasal symptoms on the visual analogue scale. The number of participants reporting symptoms between inoculation with SPN and control were statistically compared using Fishers Exact and deemed significant if P = ≤0.05. There was no significant difference in the number of participants reporting nasal (OR 0.43 [95% CI: 0.08–2.38] P = 0.449), non-nasal (OR 0.36 [95% CI: 0.07–2.00] P = 0.277) and all symptoms (OR 0.12 [95% CI: 0.01–2.21] P = 0.089).