Table 3. Comparison of 3D ADC measurement for treatment response of osteosarcoma.
| Parameters | Poor responder | Good responder | P |
|---|---|---|---|
| n = 9 | n = 2 | ||
| Pretreatment 3D ADCmean | 1472.7 [1128.1;1784.3] | 1228.4 [943.2;1513.5] | 0.480 |
| Pretreatment 3D ADCskewness | 0.3 [-0.5; 0.7] | 0.4 [-0.7; 1.5] | 0.814 |
| Pretreatment 3D ADCkurtosis | 4.7 [4.0; 5.8] | 5.4 [4.0; 6.8] | 0.637 |
| n = 13 | n = 4 | ||
| Posttreatment 3D ADCmean | 1574.3 [1309.6;1864.2] | 2053.6 [1967.2;2224.6] | 0.042* |
| Posttreatment 3D ADCskewness | -0.0 [-0.4; 0.4] | -0.9 [-1.2;-0.8] | 0.017* |
| Posttreatment 3D ADCkurtosis | 3.6 [3.0; 4.9] | 5.1 [4.2; 5.5] | 0.258 |
| n = 9 | n = 2 | ||
| Percent change 3D ADCmean | 10.6 [-2.4;20.4] | 69.8 [28.1;111.5] | 0.099 |
| Percent change 3D ADCskewness | -67.5 [-81.7;-21.3] | -31.2 [-153.6;91.3] | 1.000 |
| Percent change 3D ADCkurtosis | -21.9 [-42.6;23.4] | -1.7 [-49.8;46.4] | 0.637 |
3D ADC, apparent diffusion coefficient values derived from whole-tumor volume.
*indicates statistical significance.