. 2020 Mar 10;15(3):e0229983. doi: 10.1371/journal.pone.0229983

Table 4. Diagnostic performances of 2D ADC measurement for treatment response.

Parameters	Cutoff	Sensitivity	Specificity	AUC
Pretreatment 2D ADC_minimum
Reader 1	≤956	78%	50%	0.639
Reader 2	>765	78%	50%	0.556
Pretreatment 2D ADC_mean
Reader 1	>1011	89%	50%	0.667
Reader 2	>1001	78%	50%	0.611
Posttreatment 2D ADC_minimum
Reader 1	≤1442	85%	100%	0.885^*
Reader 2	≤1481	77%	75%	0.788^*
Posttreatment 2D ADC_mean
Reader 1	≤2079	85%	75%	0.904^*
Reader 2	≤1783	69%	75%	0.788^*
Percent change 2D ADC_minimum
Reader 1	≤37.73	78%	100%	0.889^*
Reader 2	≤39.3	100%	100%	1.000^*
Percent change 2D ADC_mean
Reader 1	≤34.73	100%	100%	1.000^*
Reader 2	≤40.51	100%	50%	0.778

2D ADC, apparent diffusion coefficient values derived from single-section regions of interest.

AUC, areas under the curve.

* indicates statistical significance.