Skip to main content
. 2020 Mar 10;15(3):e0229983. doi: 10.1371/journal.pone.0229983

Table 5. Diagnostic performances of 3D ADC measurement for treatment response.

Parameters Cutoff Sensitivity Specificity AUC
Pretreatment 3D ADCmean >943.24 89% 50% 0.667
Pretreatment 3D ADCskewness ≤1.45 89% 50% 0.556
Pretreatment 3D ADCkurtosis ≤6.33 89% 50% 0.611
Posttreatment 3D ADCmean ≤2039.17 85% 50% 0.846*
Posttreatment 3D ADCskewness >-0.82 85% 100% 0.904*
Posttreatment 3D ADCkurtosis ≤4.9 77% 75% 0.692
Percent change 3D ADCmean ≤45.1 89% 50% 0.889*
Percent change 3D ADCskewness >-153.65 100% 50% 0.500
Percent change 3D ADCkurtosis ≤39.43 100% 50% 0.611

3D ADC, apparent diffusion coefficient values derived from whole-tumor volume.

AUC, areas under the curve.

*indicates statistical significance.