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. 2020 Feb 27;14(2):e0008119. doi: 10.1371/journal.pntd.0008119

Fig 6. Intravenous injection leads to an increased worm burden in S100A8/A9-/- mice.

Fig 6

Total number of worms within the lung of WT and S100A8/A9-/- mice 4 and 7 days after L. sigmodontis infection (A) as well as adult worm burden in the thoracic cavity 12 days after intravenous infection (B). Vascular permeability (C), total number of thoracic cavity cells (D), concentrations of CXCL-1 (E), CXCL-2 (F), CXCL-5 (G) and elastase (H) in the thoracic cavity avage (TC) as well as total number of bronchoalveolar cells (I) and concentrations of CXCL-1 (J), CXCL-2 (K), CXCL-5 (L) and elastase (M) in the bronchoalveolar lavage (BAL) of 12-day L. sigmodontis-infected WT and S100A8/A9-/- mice. Results are shown as median (A-M). Statistical significance was analyzed by two-tailed non-parametric Mann-Whitney-U-test (A-B, D-M) and Kruskal-Wallis followed by Dunn’s multiple comparison test (C). *p<0.05, **p<0.01, ***p<0.001. Data shown in (A) consist of one experiment with 5 mice per group. Remaining data are pooled of three (B) and two independent experiments (C-M) with 5–8 mice per group.