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. Author manuscript; available in PMC: 2021 Jan 13.
Published in final edited form as: ACS Biomater Sci Eng. 2019 Nov 22;6(1):553–563. doi: 10.1021/acsbiomaterials.9b01241

Figure 4. Micro-CT analysis of the critical-sized craniofacial bone defect (CSD) reconstruction.

Figure 4.

(A) Images of the CSD reconstructions at 7 weeks showing calvarial 3D reconstruction, biomaterials + new bone as well as newly formed bone alone. CSD repair with BCP granules ± TBM systemically had biomaterial loss and calvarial holes. (B) Graph showing the quantitative analysis of bone volume (BV, mm3) in the region of interest. Empty defect (negative control) and BCP Granule groups had the lowest rate of bone formation compared to others (p<0.05). There was no statistical difference between BCP granule+TBM (positive control) and macroporous disks alone while the CHA+TBM group had significantly higher bone formation than BCP granule+TBM (p=0.0441).