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. 2020 Mar 6;12:1649–1660. doi: 10.2147/CMAR.S236482

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© 2020 Piao et al.

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LETM1 expression correlates with cancer epithelial cells epithelial-mesenchymal transition (EMT) in prostate cancer (PCa). (A) Western blotting analysis for the protein expression of LETM1, E-cadherin, Snail, and vimentin in PCa cell lines. β-actin was used as a loading control. (B) Tissue microarray immunohistochemistry staining of PCa for LETM1, and EMT markers E-cadherin, Snail, and vimentin (original magnification 200×). (C) and (D) Effects of silencing LETM1 in PC3 and DU145 cells on E-cadherin, Snail, and vimentin levels. (E–H) PC3 and DU145 cells’ migration and invasion ability was investigated by transwell and Matrigel invasion assays after LETM1 knockdown. **P < 0.01, ***P < 0.001 versus control.