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GSIS of pancreatic islet cells cultured in media with or without preexisting HMGB1 removal. The islets were equilibrated for 1 h in 2 mM glucose solution, and then incubated sequentially for 1 h each in 2 mM and 20 mM glucose solutions. Data are presented as mean ± SD. ****, P < .0001 as calculated by unpaired t-test.
