Table 3.
Twelve-Month Changes in Radius HRpQCT Bone Microarchitecture in Participants Randomized to the PATCH, PILL, or NONE (Controlled for Age, Height, Race and Ethnicity)
| Distal radius | LSC | PATCH (n = 24) | PILL (n = 23) | NONE (n = 26) | p (whole model) | PATCH versus PILL | PATCH versus NONE |
|---|---|---|---|---|---|---|---|
| Absolute changes in vBMD | |||||||
| Change in total vBMD (mg HA/cm3) | 13.0 | 13.03 ± 4.92 | 6.72 ± 4.92 | 9.43 ± 5.35 | 0.145 | 0.090 | 0.393 |
| Change in cortical vBMD (mg HA/cm3) | 27.0 | 31.48 ± 9.50 | 17.79 ± 9.49 | 20.29 ± 10.33 | 0.066 | 0.052 | 0.112 |
| Change in trabecular vBMD (mg HA/cm3) | 6.0 | 1.78 ± 2.34 | −0.71 ± 2.34 | −0.20 ± 2.54 | 0.227 | 0.177 | 0.299 |
| Absolute changes in bone geometry | |||||||
| Change in cortical thickness (mm) | 0.06 | 0.083 ± 0.03 | 0.026 ± 0.03 | 0.038 ± 0.04 | 0.023 | 0.017 | 0.058 |
| Change in cortical area (mm2) | 3.7 | 6.07 ± 4.04 | 0.45 ± 4.04 | 1.35 ± 4.39 | 0.076 | 0.062 | 0.115 |
| Change in trabecular area (mm2) | 2.5 | 88.0 ± 37.7 | 37.6 ± 37.7 | 50.0 ± 41.1 | 0.106 | 0.076 | 0.190 |
| Absolute changes in bone microarchitecture | |||||||
| Change in trabecular number (1/mm) | 0.31 | −0.028 ± 0.08 | −0.061 ± 0.08 | −0.049 ± 0.09 | 0.831 | 0.767 | 0.888 |
| Change in trabecular separation (mm) | 0.08 | 0.007 ± 0.02 | 0.011 ± 0.02 | 0.005 ± 0.02 | 0.869 | 0.904 | 0.989 |
| Change in trabecular thickness (mm) | 0.01 | 0.0015 ± 0.003 | 0.0016 ± 0.003 | 0.0013 ± 0.003 | 0.984 | 0.997 | 0.991 |
Data are reported as least square means ± SE. Bold values are significant. Comparisons (PATCH versus PILL) and (PATCH versus NONE) performed using Data are reported as least square means ± SE. Bold values are signi Dunnett’s adjustment for multiple comparisons.
HA = hydroxyapatite; LSC = least significant change.