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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Exp Eye Res. 2019 Oct 4;189:107825. doi: 10.1016/j.exer.2019.107825

Fig. 3.

Fig. 3.

In vivo and histological imaging of Case 2, a 6-year-old rhesus macaque with the BBS7−/− mutation. A) Color fundus photography revealed significant retinal atrophy in the macula and fovea with a lack of obvious retinal vasculature throughout the posterior pole. B) Fundus autofluorescence confirmed the lack or reduction in retinal vasculature, but also showed intense, diffuse hyperfluorescence across the posterior pole in contrast with distinct macular hypoautofluorescence indicative of pigmented epithelial cell atrophy. C) Optical coherence tomography (OCT) identified severe atrophy of all retinal layers. D) Hematoxylin and eosin staining of a section of retina (D, E and F) closely matched to the OCT section revealed severe atrophy of retinal cells in all layers, rosettes of inner retinal and glial cells (E, red outline in D) and a complete loss of outer retinal cells in the fovea (F, blue outline in D).