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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Exp Eye Res. 2019 Oct 4;189:107825. doi: 10.1016/j.exer.2019.107825

Fig. 5.

Fig. 5.

Brain MRI findings in BBS7−/− Case 3 at 4 years of age. A) Axial (top) and sagittal (bottom) images are shown for T1-weighted (T1W) images from a representative age-matched control (left), and for T1W (middle) and T2-weighted (T2W, right) images of Case 3. Levels of the images are indicated by the dashed white lines on the red 3D brain surface schematic. The brain of Case 3 appears notably smaller than the age-matched unaffected control, and a dilated posterior horn of the right lateral ventricle is indicated by hypo-intense and hyper-intense foci (red arrows) on T1W and T2W images, respectively. B) Total brain volume for Case 3 is shown compared with 18 age-matched unaffected monkeys (4.0 ± 0.25 years). In the box-and-whisker plot of the control data, open dots = individual values, box = interquartile range, middle line = median, x = mean, and whiskers = range. Total brain volume for Case 3 is reduced by 30%, or over 3 standard deviations, below the control mean.