Author response image 1. Muscimol inactivation on visual discrimination and motor control tasks.

(A) Schematic of visual discrimination task (top) in which reward was available at one visual cuebut not the other. The distance to both visual cues was equal. Animals learned to discriminate reliably (middle raster plot) and task performance was not affected by multi-site (2-4) bilateral muscimol injections into RSC A30 (bottom raster plot). (B) Behavioral D-Prime showing that all animals learned the task in ~10-12 sessions (n=4 mice). (C) D-Prime during sham and muscimol injections. (D) Top: schematic of motor control experiment where animals ran different distances to obtain rewards at either visual cue. On the short trials, mice had to travel an average of 140 cm while on the long trials they had to travel 200 cm on average. Both visual cues were rewarded. Raster plots show behavior during sham and muscimol multisite bilateral injection into RSC A30. (E,G) Running speed profiles and mean running speeds during sham and muscimol injection. (F) Task score during sham and muscimol injection.