Table 4.
Mean difference in mixed meal tolerance test parameters during treatment with metformin (study day 2 and change from study day 1 to study day 2) for women with gestational diabetes mellitus and non-pregnant women with type 2 diabetes mellitus
| Parameter | Mean difference on SD2 between study arms |
p value comparing mean value on SD2 between study arms |
p value comparing mean change from SD1 to SD2 between study arms |
|---|---|---|---|
| SI (10−4 min−1 μU−1 mL) | −1.6 (−5.2 to 1.86) |
0.3 | 0.9 |
| Φtotal (10−9 min−1) | 86 (51 to 121) |
0.00001 | 0.4 |
| Φstatic (10−9 min−1) | 76 (43 to 109) |
0.00005 | 0.4 |
| Φdynamic (10−9 min−1) | 1400 (779 to 2020) |
0.00006 | 0.7 |
| Φbaseline (10−9 min−1) | 1.4 (−2.3 to 5.1) |
0.4 | 0.001 |
| DI (10−13 min−2 μU−1 mL) | 422 (227 to 617) |
0.0001 | 0.01 |
| Peak glucose (mg/dL) | −85 (−133 to −37) |
0.002 | 0.08 |
GDM = gestational diabetes mellitus, T2DM = type 2 diabetes mellitus, SI = insulin sensitivity, Φtotal = total β-cell responsivity, Φstatic = static β-cell responsivity, Φdynamic = dynamic β-cell responsivity, Φbaseline = baseline β-cell responsivity, DI = disposition index, MMTT = mixed meal tolerance test. Results reported as mean ± standard deviation. The values for women with GDM were adjusted to account for normal gestational age-dependent. Refer to Table 2 for actual parameter values.