Table 1: Diagnostic performance of dynamic MPICT.
Summary of studies comparing dynamic stress CT myocardial perfusion imaging (MPI) against invasive coronary angiography (ICA) with fractional flow reserve (FFRcath) or other noninvasive functional tests. Sensitivity (sens), specificity (spec) and area under the curve (AUC) are listed on a per-vessel basis, and compared to CT angiography, if data available. Myocardial blood flow (MBF, ml/min/100cc myocardium), single/dual source computed tomography (SSCT/DSCT), coronary flow rate (CFR).
| Author (year) |
N | CT system (vendor) |
Dose (mSv) |
MBF Cut-off |
Reference | CTA | MPICT | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sens (%) |
Spec (%) |
AUC | Sens (%) |
Spec (%) |
AUC | ||||||
| Bamberg 2011 | 33 | 128-slice DSCT (Siemens) | 75 | ICA/FFRcath | 100 (88-100) | 51 (39-63) | 93 (77-99) | 87 (76-94) | |||
| Wang 2012 | 30 | 128-slice DSCT (Siemens) | 9.5±1.3 | NR | MPISPECT | 90 | 51 | 100 | 75.7 | ||
| Weiniger 2012 | 10 | 128-slice DSCT (Siemens) | 12.8±2.4 | Visual | MPIMRI | 86 | 98 | ||||
| MPISPECT | 84 | 92 | |||||||||
| Huber 2013 | 32 | 256 SDCT (Philips) | 9.5 | 164 | ICA >75% FFRcath ≤ 0.75 | 76 (57-90) | 100 (95-100) | 0.86 | |||
| Rossi 2014 | 99 | 128-slice DSCT (Siemens) | 78 | FFRcath ≤ 0.75 | 61 (77-94) | 77 (84-97) | 85 (69-94 | 89 (78-95) | 0.95 | ||
| Kono 2014 | 42 | 128-slice DSCT (Siemens) | 9.4 | 0.85 (index) | FFRcath ≤ 0.80 | 98 | 70 | 0.85 | |||
| Kikuchi 2014 | 32 | 320-slice SSCT (Canon) | 12.8±2.9 | 2.97 (CFR) | MPIPET | 86 | 92 | 0.90 | |||
| Tanabe 2016 | 53 | 256 MDCT (Philips) | 10.5-10.6 | 92 | MPISPECT (N=25) | 95 (52-100) | 72 (53-91) | 0.87 | |||
| 98 | MPIMRI (N=28) | 78 (67-97) | 80 (58-86) | 0.89 | |||||||
| Coenen 2017 | 74 | 128-slice DSCT (Siemens) | 9.3-1.8 | 0.71 (index) | ICA/FFRcath ≤0.80 | 78 (65-90) | 49 (38-61) | 0.70 | 73 (61-86) | 68 (56-80 | 0.75 |
| Rossi 2017 | 115 | 128/192-DSCT (Siemens) | 6.0-10.3 | 75 (index) | ICA/FFRcath ≤0.80 | 35 (21–53) | 95 (81–99) | 0.65 | 89 (76-96) | 73 (59-83 | 0.85 |
| Pontone 2019 | 85 | 256-slice SSCT (GE) | 5.3±0.7 | 101 | ICA/FFRcath | 83 75-91) | 66 (9-73) | 0.83 | 73 (63-83) | 86 (81-91) | 0.88 |
| Nishiyama 2019 | 38 | 256-slice SSCT (Philips) | 10.2±1.2 | 126 | ICA/FFRcath <0.75 | 96 (88–100) | 57 (46–67) | 0.84 | 83 (68–98) | 93 (88–98) | 0.96 |
| Alessio 2019 | 34 | 256-slice SSCT (GE) | 8.4±1.1 | 126 | 82-Rubidium PET | 75 | 83 | NR | |||