Table 3.
Biodistribution of F-18 labeled tryptophan derivative tracers in mice. The highest uptakes are indicated in bold in each row.
| Tracer | Uptake distribution | |||||
|---|---|---|---|---|---|---|
| Kidneys | Liver | Pancreas | Brain | Bone | Other | |
| 5-[18F]FEHTrp | ||||||
| Li, et al. 2010a (normal mice) | high (4.67±0.59) | high (5.92±0.69) | N/A | high (3.06±0.47) | high (2.59±1.19) | high in intestines, heart |
| Li, et al. 2010a (tumor-bearing mice) | high (4.47±0.71) | high (5.69±0.89) | N/A | high (2.97±0.76) | high (2.14±1.36) | high in intestines, heart |
| Krämer, et al. 2012b | high (2.05±0.59) | low (0.81±0.10) | high (8.50±1.64) | low (0.84±0.32) | no uptake | N/A |
| Abbas, et al. 2016c (wild-type mice) | low (7.64±1.6) | high (17.89±4.2) | high (35.47±6.7) | low (2.76±0.7) | N/A | high in heart, low in intestines |
| Abbas, et al. 2016c (Akita mice) | low (11.36±5.4) | low (4.32±1.9) | high (43.81±24.7) | low (3.50±1.6) | N/A | low in heart, intestines |
| 4/6/7-[18F]FEHTrp | ||||||
| Chiotellis, et al. 2014# | N/A | N/A | N/A | N/A | faint for 6-[18]FEHTrp | high in intestines |
| 2-[18F]FPTrp | ||||||
| Chiotellis, et al. 2013# | high | N/A | N/A | N/A | faint uptake | high in intestines |
| 5-[18F]FPTrp | ||||||
| Chiotellis, et al. 2013# | low | N/A | N/A | N/A | no uptake | high in intestines |
| 5-OH-2-[18F]FPTrp | ||||||
| Chiotellis, et al. 2016d | high (7.2±1.4) | N/A | N/A | low (0.96±0.09) | high 1.4±0.13 | N/A |
| 5-OH-2-[18F]FETrp | ||||||
| Chiotellis, et al. 2016d | high (12.1±2.2) | N/A | N/A | low (0.94±0.07) | high 2.0±0.5 | N/A |
| [18F]FPOTrp | ||||||
| He, et al. 2013e | high (3.17±1.45) | high (3.91±0.87) | high (4.66±1.33) | low (1.16±0.38) | low (1.33±0.22) | high in intestines |
| Shih, et al. 2014# | high | N/A | N/A | low | N/A | high in heart |
| 5[18F]FTrp | ||||||
| Tang, et al. 2017f# | low | low | low | low | high for L isomer | high in intestines |
| 4/5/6/7-[18F]FTrp | ||||||
| Zlatopolskiy, et al. 2018g | N/A | N/A | N/A | low (76.5±9.8) | low for 7-[18F]FTrp, high in 4/5/6-[18F]FTrp | N/A |
| 5[18F]F-AMT | ||||||
| Giglio, et al. 2017# | high at 30 min p.i. | N/A | N/A | N/A | N/A | N/A |
| 1-[18F]FETrp | ||||||
| Xin, et al. 2017h# | high | high | high | low | no uptake | high in heart |
| Michelhaugh, et al. 2017i# | low | low | high | low | no uptake | N/A |
| Xin, etal. 2019j# | high (3.48±0.45) | high (2.41±0.07) | high (16.7±0.80) | low (1.19±0.01) | low (1.03±0.33) | low in lungs |
in vivo %ID/g at 15 min p.i. (highest values);
ex vivo SUV at 70 min p.i.;
ex vivo %ID/g at 90 min p.i.;
organ/muscle SUV ratios at 60-75 minp.i.;
in vivo %ID/g at 30 min p.i. (highest values in normal mice);
based on %ID/g at 45 min p.i. data;
in vivo %ID at 120 min p.i.;
based on %ID/g at 120 min p.i. data;
based on SUVs/TAC btw 30-60 min p.i. data
ex vivo %ID/g at 240 min p.i.
uptake based on the text or figures/graphs presented in the paper (no exact values were shown in the article).
Abbreviations: [18F]FEHTrp: (2-[18F]fluoroethoxy)-tryptophan; [18F]FPTrp: (3-[18F]fhioropropyl)-tryptophan; [18F]FETrp: (2-[18F]fluoroethyl)-tryptophan; [18F]FPOTrp: (3-[18F]fluoropropyloxy)-tryptophan; [18F]FTrp: [18F]fluorotryptophan; [18F]F-AMT: [18F]fluoro-α-methyl-tryptophan; N/A: not available; %ID/g: percent injected dose/gram; p.i.: post injection; SUV: standard uptake value; TAC: time activity curve.