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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: J Bone Miner Res. 2019 Dec 12;35(3):550–570. doi: 10.1002/jbmr.3908

Figure 2: Loss of MCT4 Compromises Vertebral Bone Quality.

Figure 2:

A, A') μCT reconstruction of cortical bone from vertebral bodies of 14 mo WT and MCT4 KO mice (Scale bar = 0.5 mm). B-D) Analysis of cortical bone showing no significant difference in cortical bone volume (B), cortical bone area (C), or cortical cross-sectional thickness (D). E, E') μCT reconstruction of trabecular bone from vertebral bodies of 14 mo WT and MCT4 KO mice (Scale bar = 0.5 mm). F-H) Analysis of trabecular bone volume showing significant differences in trabecular total volume (F), trabecular bone volume (G), and trabecular bone volume fraction (H). I-K) Analysis of trabecular bone morphology showing trabecular spacing (I), trabecular number (J), and trabeculae thickness (K) in WT and MCT4 KO mice. L, M) Average vertebral body height and width in WT and MCT4 KO animals. N, N’) Representative cross-section of vertebral body trabecular bone showing increased tissue mineral density (red colored bone vs. green colored bone) in WT and MCT4 KO mice. O) Quantification of trabecular tissue mineral density using ImageJ. (n= 4 vertebrae/aminal; 5 animals/ genotype). Statistical Analysis: t-test. n.s.= not significant; *, p-value ≤ 0.05; **, p-value ≤ 0.01; ***, p-value ≤ 0.001.