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. 2020 Mar 4;11:114. doi: 10.3389/fendo.2020.00114

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Copyright © 2020 Bielawiec, Harasim-Symbor and Chabowski.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanism and effects of CBD action on various tissues during obesity. ↑, increase; ↓, decrease; CBD, cannabidiol; CB₁, cannabinoid receptor 1; CB₂, cannabinoid receptor 2; TRPV1, transient receptor potential channel of vanilloid type 1; GPR55, G protein coupled receptor 55; AMPKa2, catalytic subunit of AMP-activated protein kinase; ERK1/2, extracellular signal-regulated kinase; STATs, signal transducers and activators of transcription; PGC-1α, peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PPARγ, peroxisome proliferator-activated receptor gamma; TNF-α, tumor necrosis factor alpha; IFN-γ, interferon gamma; COX, cyclooxygenase; NO, nitrogen oxide; PGE₂, prostaglandin E2; IL-4, interleukin 4; IL-10, interleukin 10.