Table 1.

Univariate and multivariate analyses of factors associated with mortality and recurrence in urothelial carcinoma of the bladder (n = 283)

Variable	Overall survival				Recurrence
	Univariate	Multivariate			Univariate	Multivariate
		HR	95% CI	P value		HR	95% CI	P value
Age, year (> 60 vs. ≤ 60)	4.6 × 10−6	3.47	2.107–5.713	< 0.0001	0.187			NA
Gender (female vs. male)	0.19			NA	0.972			NA
Tumor size (> 3 vs. ≤ 3 cm)	0.016	1.286	0.755–2.192	0.354	0.721			NA
Multifocality (multifocal vs. unifocal)	0.947			NA	0.34			NA
Tumor stage (T2–T4 vs. Ta–T1)	8.5 × 10−7	2.292	1.308–4.016	0.004	0.964			NA
Nodal status (N1–N2 vs. N0)	4 × 10−6	2.541	1.214–5.315	0.013	0.151			NA
Histological grade (G3 vs. G1–G2)	3.7 × 10−4	2.541	0.691–2.026	0.54	0.007	1.661	1.099–2.509	0.016
Stabilin-$1_{\text{INT}}^{+}$ Mφ density (high vs. low)	1.8 × 10−4	2.371	1.477–3.803	< 0.0001	0.026	1.491	0.981–2.265	0.061
Stabilin-$1_{\text{ST}}^{+}$ Mφ density (high vs. low)	0.605				0.763			NA

Univariate and multivariate analyses. Cox proportional hazards regression model. Variables associated with survival by univariate analysis were adopted as covariates in multivariate analyses. Significant P values are shown in bold

UCB urothelial carcinoma of the bladder, Stabilin-$1_{\mathit{INT}}^{+}$Mφs stabilin-1⁺ Mφs in intratumoral regions, Stabilin-$1_{\mathit{ST}}^{+}$Mφs stabilin-1⁺ Mφs in stromal regions, HR hazard ratio, CI confidence interval, NA not applicable

HR > 1, higher risk of death; HR < 1, lower risk of death