Table 2.

Multivariate analysis of combinations of factors associated with UCB patient outcomes (mortality)

Combined variable	Univariate	Multivariate
	P	HR	95% CI	P
Stabilin-$1_{\text{INT}}^{+}$ Mφs and age	< 0.001	1.77	1.425–2.199	< 0.001
Low stabilin-$1_{\text{INT}}^{+}$ Mφ density, age ≤ 60		1
Low stabilin-$1_{\text{INT}}^{+}$ Mφ density, age > 60		3.53	1.693–7.355	0.001
High stabilin-$1_{\text{INT}}^{+}$ Mφ density, age ≤ 60		2.3	1.011–5.239	0.047
High stabilin-$1_{\text{INT}}^{+}$ Mφ density, age > 60		8.38	3.974–17.651	< 0.001
Stabilin-$1_{\text{INT}}^{+}$ Mφs and T stage	< 0.001	1.7	1.387–2.092	< 0.001
Low stabilin-$1_{\text{INT}}^{+}$ Mφ density, Ta–T1		1
Low stabilin-$1_{\text{INT}}^{+}$ Mφ density, T2–T4		2.22	1.133–4.358	0.02
High stabilin-$1_{\text{INT}}^{+}$ Mφ density, Ta–T1		1.98	1.030–3.795	0.04
High stabilin-$1_{\text{INT}}^{+}$ Mφ density, T2–T4		6.23	3.318–11.689	< 0.001
Stabilin-$1_{\text{INT}}^{+}$ Mφs and nodal status	< 0.001	1.61	1.294–2.013	< 0.001
Low stabilin-$1_{\text{INT}}^{+}$ Mφ density, N0		1
Low stabilin-$1_{\text{INT}}^{+}$ Mφ density, N1–N2		4.02	1.493–10.832	0.006
High stabilin-$1_{\text{INT}}^{+}$ Mφ density, N0		2.56	1.566–4.187	< 0.001
High stabilin-$1_{\text{INT}}^{+}$ Mφ density, N1–N2		5.28	1.933–14.431	0.001

Univariate and multivariate analyses. Cox proportional hazards regression model. Variables associated with survival by univariate analysis were adopted as covariates in multivariate analyses. Significant P values are shown in bold

UCB urothelial carcinoma of the bladder, Stabilin-$1_{\mathit{INT}}^{+}$Mφs stabilin-1⁺ Mφs in intratumoral regions, HR hazard ratio, CI confidence interval, NA not applicable

HR > 1, higher risk of death; HR < 1, lower risk of death