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. 2020 Mar 4;7:28. doi: 10.3389/fcvm.2020.00028

Figure 2.

Figure 2

Environmental factors, chromatin modifications, and mitochondrial damage. Environmental factors lead to specific epigenetic signatures as well as to alterations of mitochondrial intermediate metabolites (i.e., acetyl-CoA, FAD+, NAD+). These two processes influence each other, thus leading to a vicious cycle responsible for adverse chromatin modifications, maladaptive transcriptional programs, and vascular dysfunction. ROS, reactive oxygen species.