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. 2020 Mar 4;7:28. doi: 10.3389/fcvm.2020.00028

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Copyright © 2020 Mohammed, Ambrosini, Lüscher, Paneni and Costantino.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic showing the main epigenetic networks regulating mitochondrial functionality and cardiovascular disease. PGC1α, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; NRF1, Nuclear respiratory factor 1; mtDNMT1, Mitochondrial DNA methyltransferase 1; MT-CO (1-3), Cytochrome c oxidase subunit (I, II, III); MT-TL1, Mitochondrially encoded tRNA-Leu 1; MT-ATP (6, 8) Mitochondrially encoded ATP synthase membrane (subunit 6, 8); FOXO1, Forkhead box O3; PPAR1a, Peroxisome proliferator-activated receptor 1 alpha; GPx, Glutathione peroxidase; ERRα, Estrogen-related receptor alpha; IDH3, isocitrate dehydrogenase 3; Cyt-c, Cytochrome c; COXV, Cytochrome c oxidase subunit 5; MCAD, Medium-chain acyl-CoA dehydrogenase; CPT-1β, Carnitine Palmitoyltransferase 1 beta; PDK4, Pyruvate dehydrogenase lipoamide kinase isozyme 4; Nampt, Nicotinamide phosphoribosyltransferase; NAD⁺, Nicotinamide adenine dinucleotide; AceCS2, acetyl-CoA synthetase 2; AMPK, 5′ adenosine monophosphate-activated protein kinase; HAT1, Histone acetyltransferase 1; RBBP7, Retinoblastoma binding protein 7.