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. 2020 Mar 10;10:4437. doi: 10.1038/s41598-020-61463-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Significant association of plasma XOR activity with MAP in subjects with lower but not higher oxidative stress level. Plasma XOR activity was independently associated with MAP in subjects with a lower d-ROMs level (median <305 Carr U), but not in those with a higher d-ROMs level (median ≥305 Carr U). The best fitted line and 95% confidence interval are shown by a solid line and dark gray band, respectively. MAP was adjusted to the median values for age, gender, VFA, smoking habit, HbA1c, eGFR, ARR, and uric acid level after dividing the subjects based on lower and higher d-ROMs level. Abbreviations: XOR, xanthine oxidoreductase; MAP, mean arterial pressure; d-ROMs, derivative of reactive oxygen metabolites; VFA, visceral fat area; HbA1c, glycated hemoglobin A1c; eGFR, estimated glomerular filtration rate; ARR, aldosterone-to-renin ratio.