Table 1.
Summary of OpenPET imaging with 64Cu-PCTA-cetuximab and 18F-FDG (ip or iv).
| Mouse* | Tumor dimension (mm) | PET† | |
|---|---|---|---|
| Major axis | Minor axis | ||
| 64Cu-PCTA-cetuximab ip | |||
| Mouse-1-1 | 3 | 2 | Positive§ |
| Mouse-1-2 | 3 | 2 | Positive§ |
| Mouse-1-3 | 4 | 3 | Positive§ |
| Mouse-1-4 | 4 | 3 | Positive§ |
| Mouse-1-5 | 3 | 3 | Positive§ |
| Mouse-1-6 | 9 | 5 | Positive§ |
| 64Cu-PCTA-cetuximab iv | |||
| Mouse-2-1 | 8 | 4 | Negative |
| Mouse-2-2 | 3 | 3 | Negative |
| Mouse-2-3 | 5 | 3 | Negative |
| Mouse-2-4 | 7 | 7 | Negative |
| Mouse-2-5 | 4 | 3 | Negative |
| Mouse-2-6 | 4 | 3 | Negative |
| 18F-FDG ip | |||
| Mouse-3-1 | 4 | 3 | Negative |
| Mouse-3-2 | 8 | 4 | Negative |
| Mouse-3-3 | 4 | 4 | Negative |
| Mouse-3-4 | 7 | 4 | Negative |
| 18F-FDG iv | |||
| Mouse-4-1 | 4 | 4 | Negative |
| Mouse-4-2 | 5 | 3 | Negative |
| Mouse-4-3 | 4 | 4 | Negative |
| Mouse-4-4 | 8 | 4 | Negative |
*The OpenPET images of the following mice are shown in various figures: mouse-1-1, Fig. 2; mouse-1-3, Supplementary Fig. S3; mouse-2-2, Fig. 3; mouse-3-3, Fig. 4A; mouse-4-2, Fig. 4B. †Imaging with the small OpenPET system. Positive and negative indicate detection and no detection of tumor, respectively, by OpenPET imaging in the mice. §Similar detection with the human-sized Open-PET system.