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. 2020 Mar 10;10:4436. doi: 10.1038/s41598-020-61290-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Serum metabolic profile displayed differential metabolic features in young adults with CAP as compared to normal control. (A) 2D projection plots of metabolites from PLS-DA analysis, indicating clear separation between the young CAP and control. (B) Variable importance in projection (VIP) of metabolites and their ratios of biological significance. (C) Heatmap of the significantly altered metabolites and their ratios of biological significance in the young CAP and control.