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. 2020 Mar 10;10:4436. doi: 10.1038/s41598-020-61290-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Dysregulated metabolites were correlated to clinical inflammatory markers in young CAP. (A) Correlations between CRP, PCT, neutrophil percentage and WBC count and altered metabolites and ratios in young CAP adults. The colors in the heatmap stood for efficiency of the Pearson’s correlation. *p < 0.05, **p < 0.01. (B) Simple linear regression model with log 2 transformed CRP and relative serum Aminoadipic acid levels. The y axis represented serum Aminoadipic acid level, and the x axis represented log 2 transformed CRP. R square was 0.31, and 95% CI was −1.14 to −0.00. (C) Simple linear regression model with log 2 transformed PCT and relative serum 2-Hydroxy-3-methylbutyric acid level. The y axis represented serum 2-Hydroxy-3-methylbutyric acid level, and the x axis represented log 2 transformed PCT. R square was 0.41, and 95% CI was 0.067 to 0.58. (D) Simple linear regression model with log 2 transformed PCT and relative serum Palmitoleic acid level. The y axis represented serum Palmitoleic acid level, and the x axis represented log 2 transformed PCT. R square was 0.37, and 95% CI was −0.52 to −0.039.