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. 2020 Mar 10;11:1291. doi: 10.1038/s41467-020-15073-7

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© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Backbone trace labeling terminal residues of 15 lowest energy RAZUL (blue):AZUL (green) structures superimposing secondary structures with Zn displayed (blue sphere). Secondary structures and Zn are labeled in a, b. b Representative ribbon diagram of the RAZUL:AZUL structure with sidechain atoms of Zn-coordinating cysteines displayed as sticks with sulfur yellow. c AZUL-induced CSI change (ΔCSI) for RAZUL Cα (top) and C’ (bottom). ΔCSI(Cα) = CSI(Cα_bound) − CSI(Cα_free); ΔCSI(C’) = CSI(C’_bound) − CSI(C’_free). d CD spectra of RAZUL (blue), AZUL (green), and the mixture (orange). The theoretical sum spectrum based on free values (gray) is displayed, with a table listing predicted helicity and schematic depicting the effect of AZUL on RAZUL structure. Source data are provided as a Source Data file.