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. 2020 Mar 10;10:4409. doi: 10.1038/s41598-020-61236-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Kaplan-Meier log rank Recurrence Free Survival analysis of groups generated by a composite classification rule combining miRNA profiles and pathologically assessed chemoresponse (PCR). Three groups were defined: “Very favorable” (good prognostic profile/optimal chemoresponse, top curve), “very unfavorable” (poor prognostic profile/suboptimal chemoresponse, bottom curve) and “intermediate” (good prognostic profile/suboptimal chemoresponse, or poor prognostic profile/optimal chemoresponse, middle curve). Clustering: (A) 5 miRNA-profile/PCR, Median RFS 18 vs 202 months vs not reached, p = 0.003. (B) 22 miRNA-profile/PCR, Median RFS 21 vs 100 months vs not reached, p = 0.026. Signed average: (C) 5 miRNA-profile/PCR, Median RFS 13 vs 100 months, vs not reached, p = 0.039. (D) 22 miRNA-profile/PCR, Median RFS 16 vs 100 months vs not reached, p = 0.039.