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. 2020 Mar 10;10:4456. doi: 10.1038/s41598-020-61358-8

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© The Author(s) 2020, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Intracellular uptake of PEG-ENPs is similar to ultra-ENPs in murine macrophages. RAW cells were either mock treated or treated with Nile red labeled ultra or PEG-ENPs (100 µg), for 24 hours. Cells were fixed and counterstained with the nuclear stain, DAPI. Top panel shows mock treated cells with no detectable fluorescence. Cytoplasmic Nile Red fluorescence was detected in all ENP treated cells indicating the intra-cellular uptake of both ultra and PEG-ENPs by murine macrophages (bottom panels). No significance difference in fluorescence intensity or the number of Nile red positive cells was observed between these two different treatments. Inset shows amplified regions depicted in the box to demonstrate the presence of Nile red labeled nano-sized ENPs. Scale bar-10 µm.