Table 3.

Regulation of different inflammatory environments by members of the interleukin-12 family.

Organ	Mouse	Model	IL-12	IL-23	IL-27	IL-35	References
Heart	Wild type	Ang II	Down	–	–	–	Li et al., 2012
	Wild type	CVB3	Both	Up	Down	–	Shioi et al., 1997; Nishio et al., 2003; Fairweather et al., 2005; Jiang et al., 2014; Zhu et al., 2015
	Wild type	LLDB	Up	–		Down	Kan et al., 2016; Jia et al., 2019; Liu et al., 2019
	Wild type	IR	Up	Up	–	–	Zhu et al., 2013; Zhang et al., 2014b; Zhu et al., 2014; Hu et al., 2016; Yan et al., 2017; Liao et al., 2017
	Wild type	DOX	Down	–	–	Down	Jia, 2018; Ye et al., 2018b; Ye et al., 2018c
Aorta	Wild type	Ang II	Down	–	–	–	Ye et al., 2019
	ApoE-/-, LDLR-/-	HFD	Up	Both	Both	Down	Lee et al., 1999; Davenport and Tipping, 2003; Hauer et al., 2005; Koltsova et al., 2012; Hirase et al., 2013; Subramanian et al., 2015; Kan et al., 2016; Tao et al., 2016; Engelbertsen et al., 2018; Fatkhullina et al., 2018; Ryu et al., 2018; Huang et al., 2019; Huang et al., 2019; Wang et al., 2019; Jia et al., 2019; Liu et al., 2019

Ang II, angiotensin II; CVB3, Coxsackievirus B3; LLDB, ligation of left anterior descending branch; IR, ischemia-reperfusion; DOX, doxorubicin; HFD, high-fat diet.

Up: magnify inflammatory response.

Down: alleviate inflammatory response.

Both: both the magnification and reduction of inflammatory response were reported.