TABLE 1.

Pin1 is regulated by various post-translational modifications.

Modification type	Modification site	Enzyme	Effect on Pin1	References
Phosphorylation	S16	PKA	Inhibit binding ability and nuclear localization	Lu et al., 2002
Phosphorylation	S16	Aurora A	Inhibit binding ability	Lee et al., 2013
Phosphorylation	S16	RSK2	Increase binding ability	Cho et al., 2012
Phosphorylation	S16	COT	Increase binding ability	Kim et al., 2015
Phosphorylation	S71	DAPK1	Inhibit catalytic activity and nuclear localization	Lee et al., 2011a; Kim et al., 2014; Mahoney et al., 2018
Phosphorylation	S138	MLK3	Increase catalytic activity and nuclear translocation	Rangasamy et al., 2012
Phosphorylation	S65	Plk1	Inhibit ubiquitination and increase protein stability	Eckerdt et al., 2005
SUMOylation	K6, K63	SUMO1	Inhibit binding ability and catalytic activity	Chen et al., 2013
Oxidation	C113		Inhibit catalytic activity and nuclear localization	Chen et al., 2015
Oxidation	M130, M146		Unknown	Ando et al., 2013
Acetylation	K46		Unknown	Choudhary et al., 2009; Ando et al., 2013

PKA, cAMP-protein kinase A; RSK2, ribosomal protein S6 kinase 2; DAPK1, death-associated protein kinase 1; MLK3, mixed-lineage kinase 3; Plk1, polo-like kinase 1; SUMO1, small ubiquitin-like modifier 1.