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. 2020 Mar 10;10:4462. doi: 10.1038/s41598-020-60563-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Density plots displaying values of interferon gene signature (IFNGS) in systemic lupus erythematosus (SLE; magenta) and healthy donors (HD; grey), and four-protein IFN signature (IFNPS) in HD (grey) and patients with SLE (magenta). (b) Values of IFNGS in HD (grey) and patients with SLE with low (blue) and high (magenta) values of IFNGS (cutoff of 2), and IFNPS values in HD (grey) and patients with SLE with low (blue) and high (magenta) IFNGS. Statistical comparisons between each group of patients with SLE and HD were reported with the area under the curve (AUC) and p-value reported from the Mann-Whitney U test.