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. 2020 Mar 10;10:4462. doi: 10.1038/s41598-020-60563-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Heatmap displaying associations of cell populations with interferon gene signature (IFNGS) and interferon protein signature (IFNPS) in 3-way ANOVA (p < 0.05). (b,c) Boxplots displaying elevation of Ki-67+ NK cells and PD-1+ Tcm CD4 T cells in IFNGS-high patients with systemic lupus erythematosus (SLE) versus IFNPS-high/IFNGS-low patients with SLE. AUC = area under the curve, HD = healthy donors, SD = standard deviation, WB = whole blood. NK = natural killer cells, Tcm = central memory T cells, Tem = effector memory cell.