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. 2020 Mar 10;10:4462. doi: 10.1038/s41598-020-60563-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Boxplots displaying correlation between interferon gene signature (IFNGS) and interferon protein signature (IFNPS) with systemic lupus erythematosus (SLE) disease activity. (b) Area under the curve (AUC) of IFNGS and IFNPS in discriminating patients with SLE positive or negative for specific SLE Disease Activity Index (SLEDAI) components in the NIH lupus cohort. Threshold for leukopenia: <3,000 WBC/µl. (c) Scatterplots displaying correlation between IFNPS and SLEDAI in non-lymphopenic patients with SLE and lymphopenic patients with SLE. P-values reported using Mann-Whitney U test (***p < 0.001, **p < 0.01, *p < 0.05, ▪p < 0.10). HD = healthy donors.