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. 2020 Mar 10;10:4449. doi: 10.1038/s41598-020-61265-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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In vivo experiment with IGS-2.7. (a) Chemical structure of IGS-2.7 and its IC₅₀ values on CK-1. (b) Experimental design of i.p. administration of the compound IGS-2.7 (c) Effects of IGS-2.7 treatment on body weight gain in TDP-43 and wild-type mice. Values are expressed as means ± SEM; N ≥ 8 animals in each group. Data were assessed by repeat measures two-way ANOVA followed by the Bonferroni test (*p < 0.05, **p < 0.01, ***p < 0.001 vs. WT-Veh group; ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 vs. TDP-43-Veh).