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. 2020 Mar 10;10:4449. doi: 10.1038/s41598-020-61265-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of IGS-2.7 on phosphorylation of TDP-43 in the spinal cord of wild-type and transgenic TDP-43 mice. (a) Spinal cord lysates from wild-type and transgenic TDP-43 mice were used to determine the levels of pTDP-43 and TDP-43. (b) Representative immunoblots are shown. Densitometric analyses represent the ratio of pTDP-43/total TDP-43 and are the mean ± SEM of 8 observations per group. Data were assessed by one-way ANOVA followed by the Bonferroni test (*p < 0.05 WT-Veh group; ^#p < 0.05 vs. TDP-43-Veh).