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. 2020 Mar 10;11:1297. doi: 10.1038/s41467-020-15061-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — CaVT can act as both a translational activator and repressor. While mRNAs containing a weak binding motif are translationally activated by CaVT, mRNAs containing a strong binding motif are translationally repressed by CaVT. Through these translational regulations, CaVT can be used to control reporter expression, apoptosis induction, and genome editing. The implementation of microRNA- or small molecule responsiveness to CaVT enables cell selective or conditional regulation of these biological phenomena.