Figure 5.

Representative fits of drug action models in SCID mice infected with P. falciparum at day 0 with an inoculum of 2 × 10⁷–3.5 × 10⁷ infected RBCs. The models were fitted to data of all administered doses with model predictions for the respective doses portrayed here. Treatment commenced three days after inoculation in dosing intervals of 24 hours. Mice were treated with 4 × 30 mg/kg ACT-451840, 4 × 50 mg/kg CQ, 2 × 10 mg/kg MMV390048 or 2 × 10 mg/kg OZ439. The cessation of human RBC injections in ACT-451840 and CQ experiments seven days after treatment leads to a decay of human RBCs and therefore also parasitemia 10–15 days after treatment (a,b). The horizontal dashed line represents the lower limit of quantification with 0.01% parasitemia. n = 2 mice for all doses shown.