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. 2020 Mar 10;10:4446. doi: 10.1038/s41598-020-61441-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of hUCBCs on the IL-8-mediated upregulation of angiogenic growth factors and the endothelial marker CD31. The affected brain hemispheres of HI mice sacrificed 1 day after hUCBC administration were collected for Western blot analysis. (a) The protein levels of angiogenic growth factors VEGF, bFGF, and PDGF, and the endothelial marker CD31 were all downregulated after HI and then significantly recovered after hUCBC administration according to Western blotting. (b–e) The graphs depict the band intensity in each Western blot assay. Data are shown as the mean ± SEM (each n ≥ 5). The data were collected from triplicate results. Asterisks (*) indicate significant differences (*p < 0.05, **p < 0.01, ***p < 0.001, one-way ANOVA). HI, hypoxic-ischaemic brain injury; hUCBC, human umbilical cord blood mononuclear cells; UCB, HI mice subjected to hUCBC treatment.