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. 2020 Mar 10;10:4446. doi: 10.1038/s41598-020-61441-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic illustration of the timeline for the assessment of the effects of hUCBCs in ameliorating mouse brain lesions and behavioural outcomes. Postnatal day 7 (P7) ICR mice were conditioned for hypoxic-ischaemic brain injury. Intraperitoneal cyclosporine was administered to the hUCBC group and cyclosporine-only group beginning on P13 for 5 consecutive days (small arrows). At P14, the hUCBC group received hUCBCs (3 × 10⁷/kg) intraperitoneally, whereas IL-8 group received IL-8 (50 µg/kg) intraperitoneally. For long-term follow-up, mice were allocated to the sham, HI, cyclosporine, hUCBC, and IL-8 groups. At P21, the sham, HI, hUCBC, and IL-8 groups were assessed for angiogenesis via IHC. At P42, behavioural test of the mice was performed prior to sacrifice. Sacrifice A: sacrifice schedule for inhibition tests; Sacrifice B: for IHC and behavioural studies; HI, hypoxic-ischaemic brain injury; hUCBC, human umbilical cord blood mononuclear cells; IHC, immunohistochemistry.