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. 2020 Mar 4;11:204. doi: 10.3389/fphar.2020.00204

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Copyright © 2020 Liu, Bai, Ma, Xin, Chu, Yuan, Qiu, Ke, Yin, Chen and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of PUR on synaptic damage post-HI insult. Representative electron micrographs images indicating *: presynaptic vesicles, red arrow: postsynaptic partners, green arrow: few vesicles but no postsynaptic partner, red arrowhead: destroyed synapses, green arrowhead: widened synaptic clefts. Quantification of the number of synapses at 3, 14, and 28 days post-HI insult (N = 4/group). The number of synapses was expressed as the average of all synapses present in each photo taken at 20,000×.