Table 1.

List of key interacting residues within 4 Å of the bound probe molecules in the detected potential binding sites rendered as spheres in Figure 3D.

Site	OSM	OSMR
0	Arg36, Ile37, Gln38, Gly39, Pro93, Asp97, Leu98, Ser101, Leu103	Ile206, Arg207, Asn208, Lys209
1	Gln38, Gly39, Leu40, Leu45, Phe160, Lys163	Ser178, Cys179, Gly210, Thr211, Asn212, Tyr214,
2		Phe205, Ile206, Leu231, Phe232, Val233, Ser234, Ala264, Leu265, Gly266
3	Lys44, Leu45, His48, Phe160	Asn176, Val177, Ser178, Tyr214, Cys215, Glu216, Ser218, Gln219, Gly220, Val222
4	Arg36, Ile37, Gly39, Leu103	Ile206, Arg207, Asn208, Lys209, Gly210
5	Asp97, Leu98, Arg100, Ser101	Ile206, Ala264, Leu265, Gly266
6	Asp158, Ala159, Phe160	Gln146, Asn212, Tyr214, Val222, Lys227, Gly228, Val230
7		Ile206, Gly210, Thr211, Asn212, Leu231, Val233
8	Arg84, Asp87, Leu88, Arg91, Arg162, Glu165, Gly166
9	Arg84, Pro151, Thr152, Pro153

The identified “hot spots” by computational alanine mutagenesis were shown in bold.