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Pedigree and haplotype analysis with STR markers D5S299, D5S134, D5S346. Individual III-17 (arrow) is the proband. By PCR and electrophoresis, D5S299 alleles are designated A1-4; D5S134 alleles, B1-4; and D5S346 alleles, C1-4. Haplotype A1B4C1 (bold) segregates with the disease phenotype.
