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. 2020 Mar 4;8:62. doi: 10.3389/fbioe.2020.00062

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Copyright © 2020 Zheng, Li, Wang, Han, Hao, Wang, Ma, Yang, Ma, Yi and Peng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Models of type I Cascade complexes. (A) Structure of the type I-E Cascade of E. coli binding to a dsDNA target (PDB code: 5H9F, left) and a simulated model according to the structure (right). (B) Models for other characterized Cascade complexes of type I systems, including type I-A (Lintner et al., 2011), type I-B (Brendel et al., 2014), type I-C (Nam et al., 2012), and type I-F (Wiedenheft et al., 2011a), showing overall architectural similarities to that of the type I-E. Weakly associated subunits are indicated with dashed outline.